What to Expect with SUPREP Bowel Prep Kit

Be sure to follow your doctor’s instructions and carefully read the information that comes with SUPREP Bowel Prep Kit. Your doctor will tell you when it is time to begin taking SUPREP Bowel Prep Kit.

SUPREP is a low-volume bowel preparation that is taken as a split-dose regimen. A split-dose regimen means that you take two 6-ounce bottles of SUPREP Bowel Prep Kit. The first 6-ounce bottle is taken the evening before your colonoscopy and the second 6-ounce bottle is taken the morning of your colonoscopy.

The evening before your colonoscopy, pour the 6-ounce bottle of SUPREP liquid into the mixing container that comes with the kit. Then add cool water to the 16-ounce line on the container and mix. Drink all the liquid in the container. You MUST drink two more 16-ounce containers of water over the next hour.

Follow these same directions for preparing and taking the second 6-ounce bottle of SUPREP Bowel Prep Kit on the morning of your colonoscopy. You MUST finish drinking the final glass of water at least 1 hour before your colonoscopy.

In clinical studies, the most common side effects that people experienced with SUPREP Bowel Prep Kit were overall discomfort, abdominal distention, abdominal pain, nausea, vomiting and headache.

Call your doctor if you have any questions about taking SUPREP Bowel Prep Kit.


SUPREP ® Bowel Prep Kit (sodium sulfate, potassium sulfate and magnesium sulfate) Oral Solution is an osmotic laxative indicated for cleansing of the colon as a preparation for colonoscopy in adults. Most common adverse reactions (>2%) are overall discomfort, abdominal distention, abdominal pain, nausea, vomiting and headache. Use is contraindicated in the following conditions: gastrointestinal (GI) obstruction, bowel perforation, toxic colitis and toxic megacolon, gastric retention, ileus, known allergies to components of the kit. Use caution when prescribing for patients with a history of seizures, arrhythmias, impaired gag reflex, regurgitation or aspiration, severe active ulcerative colitis, impaired renal function or patients taking medications that may affect renal function or electrolytes. Use can cause temporary elevations in uric acid. Uric acid fluctuations in patients with gout may precipitate an acute flare. Administration of osmotic laxative products may produce mucosal aphthous ulcerations, and there have been reports of more serious cases of ischemic colitis requiring hospitalization. Patients with impaired water handling who experience severe vomiting should be closely monitored including measurement of electrolytes. Advise all patients to hydrate adequately before, during, and after use. Each bottle must be diluted with water to a final volume of 16 ounces and ingestion of additional water as recommended is important to patient tolerance.

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