Dosing

A LOW-VOLUME REGIMEN THAT IS MOSTLY WATER

The SUPREP dosing regimen
  • Two SUPREP Bowel Prep Kit doses are required for a complete preparation2

    Each dose consists of one 16‑oz cup: 6 oz of SUPREP liquid mixed with 10 oz of water

    Follow each dose with two additional 16‑oz cups of water

  • American College of Gastroenterology (ACG)-recommended split-dose regimen6

HOW MUCH DOES THE ADULT PATIENT CONSUME?

Key
SUPREP®(split-dose regimen)2

Two SUPREP doses are required for a complete preparation:

  • Each dose consists of 6 oz of SUPREP liquid mixed with 10 oz of water
  • Each dose is followed by two additional 16‑oz cups of water
SUPREP (split-dose regimen)
SUTAB® (split-dose regimen)11

Two SUTAB doses are required for a complete preparation:

  • Dose 1 consists of 12 tablets and 16 oz of water
  • Dose 2 consists of 12 tablets and 16 oz of water
  • Each dose is followed by two additional 16 oz of water
Plenvu (split-dose regimen)11
Plenvu®* (split-dose regimen)12

Two Plenvu doses are required for a complete preparation:

  • Dose #1 consists of approximately 16 oz of Plenvu solution (112-gram packet mixed with water)
  • Dose #2 consists of approximately 16 oz of Plenvu solution (100-gram packet mixed with water)
  • Each dose is followed by at least 16 oz of clear liquid
Plenvu (split-dose regimen)11
Clenpiq®†(split-dose regimen)13

Two Clenpiq doses are required for a complete preparation:

  • Dose #1 consists of one 5.4 oz bottle of Clenpiq solution followed by five 8-oz cups (40 oz) of clear liquid consumed within a 5-hour period
  • Dose #2 consists of one 5.4 oz bottle of Clenpiq solution followed by at least three 8-oz cups (24 oz) of clear liquid, to be finished 2 hours before the colonoscopy
Clenpiq (split-dose regimen)12Clenpiq (split-dose regimen)12
Standard 4-Liter Prep
(day-before regimen)5

Single dose consists of approximately 135 oz of solution (divided into approximately seventeen 8-oz servings) consumed within a 4-hour period.

Standard 4-Liter Prep (day-before regimen)5
MiraLAX®§+ Gatorade®||
(split-dose regimen)14

Two doses required for a complete preparation:

  • Dose #1 consists of 2 Dulcolax®¶ tablets followed by 33.8 oz of Gatorade mixed with 119g of MiraLAX
  • Dose #2 consists of 33.8 oz of Gatorade mixed with 119g of MiraLAX
MiraLAX + Gatorade®||
(split-dose regimen)13

IMPORTANT SAFETY INFORMATION

SUPREP® Bowel Prep Kit (sodium sulfate, potassium sulfate and magnesium sulfate) Oral Solution is an osmotic laxative indicated for cleansing of the colon as a preparation for colonoscopy in adults and pediatric patients 12 years of age and older. DOSAGE AND ADMINISTRATION: Each bottle must be diluted with water to a final volume of 16 ounces (Adults) and 12 ounces (Pediatric patients 12 years of age and older). Must consume additional water after each dose. Stop consumption of all fluids at least 2 hours prior to the colonoscopy. CONTRAINDICATIONS: Use is contraindicated in the following conditions: gastrointestinal (GI) obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, gastric retention, hypersensitivity to any ingredients in SUPREP Bowel Prep Kit. WARNINGS AND PRECAUTIONS: Risk of fluid and electrolyte abnormalities: Encourage adequate hydration, assess concurrent medications, and consider laboratory assessments prior to and after each use; Cardiac arrhythmias: Consider pre-dose and post-colonoscopy ECGs in patients at increased risk; Seizures: Use caution in patients with a history of seizures and patients at increased risk of seizures, including medications that lower the seizure threshold; Patients with renal impairment or taking medications that affect renal functions: Use caution, ensure adequate hydration and consider laboratory testing; Suspected GI obstruction or perforation: Rule out the diagnosis before administration; Patients at risk for aspiration: Observe during administration. ADVERSE REACTIONS: Most common adverse reactions: Adults: (> 2%) are overall discomfort, abdominal distention, abdominal pain, nausea, and vomiting; Pediatric Patients (>10%) are nausea, abdominal pain, abdominal bloating and vomiting. DRUG INTERACTIONS: Drugs that may increase the risk of fluid and electrolyte abnormalities.


View the Full Prescribing Information and Medication Guide.

References: 1. IQVIA. National Prescription Audit Report. December 2020. 2. SUPREP Bowel Prep Kit [package insert]. Braintree, MA: Braintree Laboratories, Inc; 2020. 3. Di Palma JA, Rodriguez R, McGowan J, Cleveland M. A randomized clinical study evaluating the safety and efficacy of a new, reduced-volume, oral sulfate colon-cleansing preparation for colonoscopy. Am J Gastroenterol. 2009;104(9):2275-2284. 4. Rex DK, Di Palma JA, McGowan J, Cleveland M. A comparison of oral sulfate solution with sodium picosulfate: magnesium citrate in split doses as bowel preparation for colonoscopy. Gastrointest Endosc. 2014;80(6):1113-1123. 5. Rex DK, Di Palma JA, McGowan J, Cleveland M. A randomized clinical study comparing reduced-volume oral sulfate solution with standard 4-liter sulfate-free electrolyte lavage solution as preparation for colonoscopy. Gastrointest Endosc. 2010;72(2):328-336. 6. Rex DK, Johnson DA, Anderson JC, Schoenfeld PS, Burke CA, Inadomi JM; American College of Gastroenterology. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol. 2009;104(3):739-750. 7. Rex DK, Schoenfeld PS, Cohen J, et al. Quality indicators for colonoscopy. Gastrointest Endosc. 2015;81(1):31-53. 8. Cleveland M, Zamora C, Pelham R. PEG-sports drink bowel prep: physiology of electrolyte imbalance. Poster presented at: American College of Gastroenterology Annual Meeting; October 16-21, 2015; Honolulu, Hawaii. Abstract 1482. 9. Patel V, Nicar M, Emmett M, et al. Intestinal and renal effects of low-volume phosphate and sulfate cathartic solutions designed for cleansing the colon: pathophysiological studies in five normal subjects. Am J Gastroenterol. 2009;104(4):953-965. 10. Pelham RW, Alcorn H Jr, Cleveland M. A pharmacokinetics evaluation of a new, low-volume, oral sulfate colon cleansing preparation in patients with renal or hepatic impairment and healthy volunteers. J Clin Pharmacol. 2010;50(3):350-354. 11. SUTAB® [package insert]. Braintree, MA: Braintree Laboratories, Inc; 2020. 12. Plenvu [package insert]. Amsterdam, the Netherlands: Norgrine B.V.; 2018. 13. Clenpiq [package insert]. Parsippany, NJ: Ferring Pharmaceuticals Inc; 2018. 14. Matro R, Daskalakis C, Negoianu D, et al. Randomised clinical trial: polyethylene glycol 3350 with sports drink vs. polyethylene glycol with electrolyte solution as purgatives for colonoscopy – the incidence of hyponatraemia. Aliment Pharmacol Ther. 2014;40(6):610-619. 15. Data on file. Braintree Laboratories, Inc. Braintree, MA.